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It is associated with high perinatal mortality, thick fissured skin, marked ectropion (eyelid eersion), eclabium (eersion of the lips), and flexion deformities. 常伴有圍産期高死亡率、皮膚肥厚、顯著的眼瞼外繙、脣外繙和關節彎曲畸形。