mortal sin

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Let not sin reign in your mortal bodies, to make you obey their passions.
不要容罪在你们必死的身上作王，使你们顺从身子的私欲。
bolchicago.org
Venial sins lessen our fervour, lead us gradually to fall into mortal sin, and make us deserve much temporal punishment. (Sir 19:1; Mt 12:36)
答：减少人的热心，使人渐渐陷于大罪，又使人应受许多的暂罚。（德19：1；玛12：36）
So for those who think that just because an open core application or any application runs on Linux, therefore charging for the code is some sort of mortal sin, that is just ludicrous dude.
所以，如果有人要认为，具备开放核心的应用程序或其他任何应用程序，只要它们是运行在Linux上，进行代码相关收费就是弥天大罪的话，对这些人的荒谬绝伦，我们大可嗤之以鼻。

Too many are now afraid they'll be accused of being "judgmental, " the secular equivalent of a mortal sin.
FORBES: Fact and Comment
Openly criticizing the Civil Rights movement is a mortal sin for politicians, even southern Republicans who obviously attempt to capitalize on lingering racial animus.
FORBES: The Anti-Putin Opposition and the US Civil Rights Movement
But the Court held that it was up to Congress to decide whether to use tax dollars for abortions, lest some individuals be required to fund activities that they regarded as a mortal sin.
FORBES: Should The Government Fund Abortions?

in the Roman Catholic religion, an action that is so bad that you will be punished for ever after your death if you do not ask God to forgive you

In the Roman Catholic Church, a mortal sin is an extremely serious sin. Catholics believe the person who has committed it will be punished after death unless they are forgiven by the Church.