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Amylin Pharmaceuticals Inc. of San Diego, which bought the rights to leptin from Amgen Inc. in 2006, is testing it, in combination with pramlintide, a diabetes drug. 但在此前研究中，研究对象摄入瘦素替代品后，成功地逆转了这一新陈代谢变化过程，进而保持了减肥成果。